Our results revealed that compared with the normal subjects, IFN-γ, TNF-α, and IL-12 levels were decreased and IL-4, IL-6, and IL-1β levels were increased in the active TB patients and the latent TB patients, while compared with the latent TB patients, IFN-γ, TNF-α, and IL-12 levels were decreased and IL-4, IL-6, and IL-1β levels were increased in the active TB patients. This evidence concerns the gene IL4 and tuberculosis.