Our second aim was to determine at day 7 the association between circulating miRNA expression and changes in serum neutrophil gelatinase–associated lipocalin (NGAL) [24], Screa [5], the inflammatory markers procalcitonin (PCT) and IL-6 [25], and AKI stage [5] to assess the potential of these small RNAs as pathophysiological markers or therapeutic targets in septic patients with or without AKI. The gene discussed is IL6; the disease is acute kidney injury.