Loss of function mutations in EFNB1 lead to craniofronto-nasal syndrome (CFNS) a genetic condition characterized by a wide range of phenotypic effects including frontonasal dysplasia, craniofacial asymmetry, craniosynostosis, bifid nasal tip, grooved nails, wiry hair, and skeletal abnormalities [66–68]. This evidence concerns the gene EFNB1 and frontonasal dysplasia.