Indeed, Hiltzik and colleagues recently proposed the entity “non-solid/trabecular/insular type of poorly differentiated carcinoma” which had high-grade features (increased mitoses and tumor necrosis) [41], and a Ki-67 index of ≥ 4% in tumors fulfilling the “Hiltzik criteria” was an independent predictor of cause-specific survival in an independent series [42]. This evidence concerns the gene MKI67 and neoplasm.