In order to determine differences in the response to systemic CS treatment in patients with severe asthma, we analysed the behaviour of ten cell populations and parameters: neutrophils, eosinophils, total lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, NK cells, NKT cells, B cells and the CD4+/CD8+ ratio before and after intravenous treatment with CS. This evidence concerns the gene CD4 and asthma.