Accordingly, in the present study, we aimed to compare the diagnostic utility of the SAW biosensor with other antibody‐based assays (IFMA to measure aMMP‐8 and ELISA to measure total MMP‐8 [tMMP‐8]) in subjects with periodontal health, gingivitis, and periodontitis before and after treatment. The gene discussed is MMP8; the disease is periodontitis.