ATF3 and neuropathy: In nerve transection mouse models of neuropathic pain, there is a downregulation within the sensory ganglionic neurons of neuron-specific genes, similar to our findings, yet there is also the induction of injury-induced genes like Atf3, which was not observed in our transcriptomic analysis of the DRG of DPN individuals, possibly because of the different nature of the neuropathy or the clinical versus experimental time-course53.