tRNAs are the dominant m7G modified RNA species35–37, and overexpression of m7G modified tRNAs ValAAC and LysCTT could rescue the downstream target expression and ESCC growth and progression, suggesting that METTL1 facilitates target mRNA translation and ESCC progression by regulating the m7G modification and expression of tRNAs but not other RNA species37–40. Here, METTL1 is linked to esophageal squamous cell carcinoma.