We also found that there were increased Pdl1 and Pd1 staining in breast tumor tissues from Brca1Co/Co;MMTV-Cre treated either with Tas for S100A9 or AMD3465 which is an inhibitor for CXCR4, a receptor for CXCL12 (Supplementary Fig. 7m–p). The gene discussed is CXCL12; the disease is breast neoplasm.