Consistent with this notion, M1 like macrophages with double-positive markers of F4/80 and CD86 only showed more infiltration in Brca1-MT mammary glands (MTMG) than that in WT (p > 0.05), but significantly decrease in Brca1-MT tumor adjacent, and tumor mammary tissues compared to WT mammary gland (WTMG) (Supplementary Fig. 1h, j). The gene discussed is BRCA1; the disease is neoplasm.