To identify intrinsic factors that contribute for enrichment of tumor permissive microenvironment, we conducted analyses with Data-independent acquisition-Mass Spectra (DIA-MS) to mammary glands of 8–10 months wild-type (WTMG), Brca1Co/Co;MMTV-Cre (MTMG), tumor adjacent mammary gland (Tumor-adjacent MG), and breast tumor tissues from both WT (WTBT) and Brca1Co/Co;MMTV-Cre (Brca1-MTBT) at different developmental stages of tumorigenesis in mice (Fig. 2a and Supplementary Data 2). The gene discussed is BRCA1; the disease is neoplasm.