Next, we compared the 632 and 725 protein lists with top 45 human homolog genes which are negatively regulated by BRCA1 (Fig. 2e–g and Supplementary Fig. 2b), 4 commonly shared proteins, including S100A9, which plays an important role in inflammation, tumor progression and metastasis28,29, S100A8, a partner of S100A930, PGLYRP1, and COLGALT1, were identified. This evidence concerns the gene S100A8 and neoplasm.