Tumor growth effects were not associated with changes in animal weight or survival (Fig. 2d, e), nor was GSNO treatment found to induce in any direct cytotoxic or cytostatic effects on B16F10-OVA cells in vitro (Supplementary Fig. 21) or proliferation in vivo, as suggested by no change in frequencies of Ki-67+ CD45− cells (Fig. 2h). This evidence concerns the gene MKI67 and neoplasm.