In contrast, Rorc(t)CreTgTet1fl/flTet2fl/+Tet3fl/fl mice were healthy, displayed no splenomegaly or lympho-adenopathies and had equivalent proportions of naive CD44-CD62L+ T lymphocyte compartments as control mice (Supplementary Fig. 7e). This evidence concerns the gene CD44 and Splenomegaly.