Consistent with this notion, in tumor samples harvested at the endpoint (day-17), the circuit-introduced parental LLC group showed substantial increases in not only the direct immunostimulatory targets of the IFNγ axis (e.g., STAT1 and MHC molecules), but also markers for T cell activation and their cytotoxic function, including the mRNAs for CD25, CD69, Granzyme B and Perforin (Fig. 6d). Here, PRF1 is linked to neoplasm.