TRIM26 and major depressive disorder: The GWAS catalogue in FUMA identified signal overlaps amongst SNPs in linkage disequilibrium with wellbeing index and related traits; on chromosome 2, FSHR was associated with hedonic wellbeing [9] and both loci on chromosome 6 – the first associated with many related conditions including positive-affect, wellbeing spectrum [9], and depression [8, 29], and the second centred around TRIM26 associated with autism and schizophrenia [37, 38] (Table S5).