SHANK2 and Anxiety: Similarly adult restoration of Shank3 expression in 2- to 4.5-month-old Shank3−/− mice only partially prevented ASD-associated behavioural phenotypes [87], and clioquinol-induced increases in free zinc in 2- to 4-month-old Shank2−/− mice recovered social interaction deficits but did not restore defective social novelty recognition behaviour nor normalise heightened anxiety [37].