FAM163A and neoplasm: Subsequently, after preliminary screening using overall survival analysis and a series of functional experiments, we identified reported oncogenes that were important for the malignant NB phenotype, FAM163A. According to previous studies, FAM163A, which is also called NB-derived secretory protein (NDSP) or C1OEF76, has tumour specificity in NB and activates the extracellular regulated kinase (ERK) signalling pathway by combining with multiple 14-3-3 family members to promote the proliferation of tumours [47, 48, 60].