Recurrent TNFRSF14 mutations in DHLs lead to reduced expression of HVEM [19, 20, 22, 23, 78], a TNFR family protein and tumor suppressor which inhibits BCR signaling, abnormal stroma activation, and CD40 signaling through BTLA stimulation [133, 134]. The gene discussed is TNFRSF14; the disease is neoplasm.