Preclinical experiments have shown that B-AP15 promotes apoptosis by inhibiting the activity of proteasome DUB (USP14 and UCHL5) in GCB and ABC-DLBCL cell lines [338], and inhibits WNT/β-catenin and TGFβ/Smad pathways to prevent DLBCL tumor cells migration. The gene discussed is USP14; the disease is diffuse large B-cell lymphoma.