A study of 105 DLBCL patients showed that when the PD-L1 gene is altered, increased PD-L1 protein downregulated HLA expression, activated NF-κB, and higher response to PD-1 blockade (anti-PD-1 antibody pembrolizumab) were observed (NCT01953692) [306]. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.