Venetoclax, a BCL2 inhibitor with good efficiency in leukemia, was observed with limited activity in DLBCL patients with ORR only at 18% [185], and is now being tested as a regimen in several combination therapies including chemotherapy [228], radiotherapy [229] and targeted therapy, such as PI3K, BTK and SYK inhibitors (Fig. 3) [185, 188, 230]. This evidence concerns the gene BTK and diffuse large B-cell lymphoma.