In similar fashion, protein biomarkers reduced in the circulation of COVID-19 patients relative to age/sex-matched healthy controls (i.e., Stem Cell Factor (SCF) and Tumor Necrosis Factor-related Activation induced Cytokines (TRANCE), were inversely correlated with traditional inflammatory measures such as ferritin and CRP (Fig. 1A, B). This evidence concerns the gene TNFSF11 and COVID-19.