Moreover, elevated levels of proinflammatory molecules including CCL2, IL-1b, IL-8, FosB, C-X-C motif ligand (CXCL)-1 and CXCL2 have been documented in the cerebrospinal fluid (CSF) and spinal cord of ALS patients [109, 179, 181, 182]. This evidence concerns the gene IL1B and amyotrophic lateral sclerosis.