CD53 and neoplasm: The density of cell surface antigen was controllable through adjusting the dose of F-AgNPs, with F-AgNPs containing 20 μg DSPE-PEG-EvIII created almost saturated modification of 106 tumor cells without affecting cell viability, and the cell-surface antigen modification strategy suggested favorable stability (Fig. 2c, d and Additional file 1: Fig. S4).