In summary, applying a plethora of various pathological conditions (high-fat diet, H/R, ischemia/reperfusion, LPS, DOXO, Il-1α, IL-1β, TNFα, IL-17α, Ang II, hyperglycaemia, or an oxidative stress generator) most literature clearly indicates that SGLT2is directly reduce inflammation and/or oxidative stress in various cell types under these pathological conditions. This evidence concerns the gene TNF and Hyperglycemia.