The effects of lovastatin were largely rescued by cholesterol or mevalonate addition, but this rescue was absent when ERRα expression was downregulated by XCT790, suggesting that the sensitizing effect of lovastatin on NSCLC EGFR-TKIs resistant cells are ERRα-dependent in vitro (Fig. 6b, c). Here, ESRRA is linked to non-small cell lung carcinoma.