Compared with siRNAs/shRNAs targeting uPAR, siRNAs targeting uPAR and uPA or siRNAs targeting uPAR and cathepsin B exerted a better antitumor effect by inhibiting tumour cell proliferation, migration and invasion and angiogenesis and promoting tumour cell apoptosis [70, 194–198]. Here, PLAU is linked to neoplasm.