In endothelial cells and glioblastoma cells, silencing the expression of uPA/uPAR inhibits tumour angiogenesis by increasing the expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and increasing the secretion of soluble vascular endothelial growth factor (VEGF) receptor (VEGFR) 1 (SVEGFR1) [70]. Here, PLAU is linked to neoplasm.