For example, an adenoviral vector containing the uPAR antisense sequence (Ad-uPAR), an adenovirus containing uPAR antisense and p16 sense expression cassettes (Ad-uPAR/p16), an adenovirus expressing antisense uPAR and uPA sequences (Ad-uPAR-uPA), an adenovirus vector containing antisense uPAR and cathepsin B sequences (Ad-uPAR-Cath B), and an adenovirus expressing antisense uPAR and MMP-9 sequences (Ad-uPAR-MMP-9) were all successfully constructed and inhibited tumour growth and metastasis in gliomas and lung cancer models [189–193]. This evidence concerns the gene PLAU and central nervous system cancer.