Given the contribution of senescence to tumorigenesis, Amor et al. also developed an anti-uPAR CAR T-cells (m.uPAR-h.28z CAR T cells) by linking an anti-murine uPAR single chain variable fragment and human CD28 costimulatory and CD3ζ signalling domains to transduce human T-cells that efficiently cleared uPAR-expressing KP lung cancer cells, accompanied by increased secretion of granzyme B and IFN-γ. This evidence concerns the gene PLAUR and lung carcinoma.