Subsequently, RNA interference (RNAi) technologies, including siRNAs and short hairpin RNAs (shRNAs) targeting uPAR (siRNAs against uPAR, siRNAs against uPAR and cathepsin B, siRNAs against uPA and uPAR, shRNAs against uPAR, and shRNAs against uPA and uPAR), were developed to prevent tumour progression. This evidence concerns the gene CTSB and neoplasm.