Miller-Kleinhenz et al. prepared Wnt/LRP5/6- and uPAR-targeted ultrasmall magnetic IONPs carrying Dox (iWnt-ATF24-IONP-Dox) that showed a stronger inhibitory effect than non/single-targeted IONPs on a human breast cancer patient-derived xenograft model and markedly inhibited Wnt/β-catenin signalling and the cancer stem-like phenotype by decreasing the levels of the Wnt ligand, CD44 and uPAR [163]. This evidence concerns the gene PLAUR and breast cancer.