Chen et al. designed an active targeting phototherapeutic agent by conjugating zinc phthalocyanine (ZnPc) with ATF (ATF-ZnPc), which not only exhibited a high binding affinity and potent PDT activities to uPAR-positive U937 and H1299 cells, but also was used as a biomarker for the noninvasive imaging of tumours [178]. This evidence concerns the gene PLAU and neoplasm.