Lee et al. engineered ATF-mediated IONPs carrying gemcitabine (Gem) (ATF-IONP-Gem) to target uPAR-expressing tumour and stromal cells and overcome the tumour–stromal, which not only provided contrast enhancement in MRI of tumours, but also significantly inhibited the growth of orthotopic pancreatic cancer [164]. This evidence concerns the gene PLAUR and neoplasm.