They demonstrated that after angiotensin II infusion at the 4th week, STIM1 expression in the cardiovascular system of wild-type mice was enhanced, which was found to be associated with hypertension and endothelial dysfunction; however, hypertension was induced by angiotensin II, that significantly reduced in stromal interaction molecule1 SMC−/−mice [81]. The gene discussed is STIM1; the disease is hypertensive disorder.