Similarly, Chen et al. have figured out that HUCMSCs-exo represses bone tissue apoptosis in rats with necrosis of the femoral head (Li et al. 2019), and a recent document has unearthed that the upregulation of miR-140-3p reduces IL-1β-induced apoptosis of CHON-001 chondrocyte cells in osteoarthritis (Ren et al. 2020). The gene discussed is IL1B; the disease is osteoarthritis.