Gain- and loss-of-function assays were used to assess the roles of altered miR-140-3p and SGK1 in the development of RA, and one of the results of both animal and cellular experiments indicated that HUCMSCs-exo, exosomal miR-140-3p or silenced SGK1 are able to restrain the inflammation response and oxidative stress in RA. The gene discussed is SGK1; the disease is rheumatoid arthritis.