In addition, kf reductions were reported in the hippocampus, temporal lobes, parietal cortex and posterior cingulate in people with AD (Giulietti et al., 2012) and T1 and T2 relaxometry measurements have been found sensitive to AD pathology in animal and human imaging studies (Knight et al., 2016; Knight et al., 2019; Tang et al., 2018). This evidence concerns the gene AFMID and Alzheimer disease.