MAPT and Alzheimer disease: Furthermore, subiculum and CA1 regions have been proposed to be particularly vulnerable in aMCI and AD (Adler et al., 2018; Khan, et al., 2015; Lindberg et al., 2017) and in asymptomatic individuals with positive amyloid and tau cerebrospinal fluid (CSF) biomarkers (Tardif et al., 2018).