SLC46A1 and metabolic disease: In 2006, following the link between mutations in the SLC46A1 gene and Hereditary Folate Malabsorption (HFM) syndrome, a metabolic disorder that results in severe developmental and neurological abnormalities [7,8], a new transporter for dietary folates, the proton-coupled folate transporter, PCFT (SLC46A1), was discovered [9].