INS and type 2 diabetes mellitus: A link between POPs and T2D is further supported by preclinical evidence; for instance, dietary POPs derived from fatty fish impair insulin sensitivity (measured by hyperinsulinemic-euglycemic clamp) in rats by reducing insulin-stimulated glucose uptake in skeletal muscle and adipose tissue, and insulin-mediated suppression of glucose production in the liver (Ruzzin et al. 2010).