In contrast, although HDAC7 mRNA and protein levels were not dysregulated in SSc skin fibroblasts, siRNA‐mediated silencing of HDAC7 in cultured SSc fibroblasts reduced both constitutive and transforming growth factor beta‐1 (TGF‐β1)‐inducible production of type I and III collagens [143]. The gene discussed is TGFB1; the disease is systemic sclerosis.