Contrarily, Boudria et al. [148] found increased VEGF165b levels after treatment of lung adenocarcinoma cells with a high VEGF165b expression with bevacizumab, which indicates that there is crosstalk between VEGF165b, VEGFR-2 and β1 integrin proteins, promoting an invasive phenotype in these tumors. Here, KDR is linked to lung adenocarcinoma.