IFIH1 and interstitial lung disease: In particular, myositis-specific autoantibodies (MSAs), such as the anti-aminoacyl-tRNA-synthetase (ARS) antibodies and anti-melanoma differentiation factor 5 (MDA5), are associated with a high prevalence of ILD, which can precede, follow or be concomitant with the onset of skin or muscle manifestations, but tends to appear early in the disease course [45].