Furthermore, exosomes expressing transforming growth factor β1 (TGF-β1) and binding to NKG2D may downregulate NKG2D expression, reducing natural killer (NK)-induced cytotoxicity.(6)Moreover, exosomes are involved in communication with cells in the tumor microenvironment and chemoresistance in several solid neoplasms.(7,8). The gene discussed is KLRK1; the disease is neoplasm.