Fig 5A illustrates that APC expression had low correlation with OS, which means poor prognosis of pheochromocytoma and paraganglioma (P = 9e-06), whereas APC expression was highly correlated with disease-free survival (DFS) for cancer of BLCA (P = 0.0016) for the TCGA project. Also, down regulation of the APC was correlated to poor DFS prognosis for TGCT (P = 0.018). This evidence concerns the gene APC and paraganglioma.