APC and colon adenocarcinoma: The data in Fig D also reveal that low APC expression can promote MSI in KICH (P = 0.017), DLBC (P = 0.00017), HNSC (P = 0.00027), THCA (P = 1.4e-06), SKCM (P = 0.0064), BRCA (P = 0.043), BLCA (P = 0.041) and PRAD (P = 2.6e-10) (Fig 6D) but inhibit MSI formation for READ (P = 0.029), stomach adenocarcinoma (STAD) (P = 0.044), COAD (P = 0.00011), mesothelioma (MESO) (P = 0.0064), SARC (P = 0.037), cervical and endocervical cancers (CESC) (P = 0.049), UCEC (P = 0.0086) and LUSC (P = 0.00027).