APC and rectum adenocarcinoma: Truncated mutation of APC was the main type of genetic alteration, and R1450+ changes were present in 1 case of cervical squamous cell carcinoma, 8 cases of rectal adenocarcinoma, 20 cases of COAD, 6 cases of mucinous adenocarcinoma of the colon and rectum, 1 case of tubular stomach adenocarcinoma, 1 case of diffuse type stomach adenocarcinoma and 7 cases of uterine endometrioid carcinoma (Fig 6B), which is evidence of APC protein truncation.