Compared with patients who had no APC alteration, colorectal adenocarcinoma patients with altered APC had poor OS (P = 0.628), PFS (P = 0.277), DFS (P = 0.450) and DSS (P = 0.334), but patients with altered APC, such as UCEC patients, had a better OS (P = 6.02e-4), PFS (P = 3.952e-5), DFS (P = 8.154e-4) and DSS (P = 6.664e-3) (Fig 6C). Here, APC is linked to colorectal adenocarcinoma.