APC and neoplasm: In summary, our first pan-cancer analysis of APC shows that increased APC expression in the brain or on cell membranes and APC expression is statistically correlated with clinical prognosis, cancer pathological staging, DNA methylation, protein phosphorylation, immune cell infiltration, and genetic alteration in various tumors, which is helpful to understand the role of APC in tumorigenesis based on clinical tumor samples combined with clinical parameters.