If we infer LR interactions on the basis of correlation, then the ligand TNFSF10 secreted from the malignant cell interacts with the receptor TNFRSF10B on malignant and fibroblast cells (circled in green), indicating likely apoptosis of malignant cells and cancer-associated fibroblasts (Fig. 1C, left). This evidence concerns the gene TNFRSF10B and cancer.