As inflammation is a known contributor of muscle wasting (Raj et al., 2008; Schaap et al., 2006; Verzola et al., 2017), and since hyperphosphatemia and excess FGF23 are associated with inflammation, we explored whether hyperphosphatemia contributes to skeletal muscle wasting, and if pathologic FGF23-FGFR4 signaling is involved in these effects. Here, FGF23 is linked to hyperphosphatemia.