COL4A3 and hyperphosphatemia: To determine if reducing hyperphosphatemia limits skeletal muscle wasting, an important complication of CKD (Verzola et al., 2019), we analyzed skeletal muscle from wild-type (Col4a3+/+) and Alport (Col4a3−/−) mice subjected to either a normal diet (0.6% Pi) or a low Pi diet treatment (0.2% Pi) (Figure 3).