However, this work cannot exclude the potential of alternative FGFR isoforms which might mediate the effects of excess FGF23 toward functional iron deficiency following either adenine or 3% Pi diet, as a previous report exhibits the utilization of a single intraperitoneal injection of FGF23 blocking peptide was sufficient to rescue anemia (Agoro et al., 2018). Here, FGF23 is linked to anemia (phenotype).