NFE2L2 and myocardial ischemia: Silent information regulator 1 (Sirt1), a nicotinamide adenine nucleotide (NAD)-dependent protein deacetylase, has been shown to positively regulate the level of expression and activity of Nrf2 and participate in the process of cisplatin-induced nephrotoxicity, myocardial ischemia/reperfusion, and tumor drug resistance [22–24].