In the univariate analysis of all patients, modified albumin–bilirubin (ALBI) grade19, 20 (2b/3 vs. 1/2a: HR 0.45; 95% CI, 0.26–0.78; p = .0047), intrahepatic tumor volume (<50% vs. ≥50%: HR 3.31; 95% CI 1.47–7.45; p = .0038), DCP (<400 vs. ≥400: HR 2.23; 95% CI 1.28–3.89; p = .0047), and AFP (<400 vs. ≥400: HR 1.90; 95% CI 1.02–3.53; p = .042) were all associated with OS. The gene discussed is ALB; the disease is neoplasm.