Among the patients treated with lenvatinib, in the univariate analysis, intrahepatic tumor volume (<50% vs. ≥50%: HR 44.1; 95% CI 3.77–515; p = .0025), and AFP(<400 vs. ≥400: HR 2.95; 95% CI 1.16–7.51; p = .023) were associated with PFS. The gene discussed is AFP; the disease is neoplasm.