The genetics of CRC have been analysed in considerable detail and a small number of oncogenic mutations (APC, TP53, Kr‐RAS, PI3K, RNF‐43, RSPO fusions, B‐RAF, β‐catenin, TGF β receptor, SMAD 2,3,4 and the mismatch repair enzymes) drive this cancer4; thus, there is sufficient variation caused by different combinations and locations of these mutations to make CRC a genetically diverse disease. Here, RSPO1 is linked to colorectal carcinoma.