Given the increased potency of PPh in the presence of a pro‐apoptotic drug, it is conceivable that a dual drug treatment (Wnt inhibitor plus a pro‐apoptotic drug) could also kill colon adenoma stem cells (most of which have APC mutations53) and thus act as a chemoprevention strategy for reducing the incidence of colorectal cancer. This evidence concerns the gene APC and colon adenoma.