VEGF-C mRNA has been shown to be a potential tool for anti-glioma immunity enhancement in mice.23 In this study, we designed an engineered mRNA of VEGF-C comprising an activated form of VEGF-C41 and immunoglobulin kappa (Igκ),42 an artificial signal peptide at the N-terminus of the activated form of VEGF-C (Supplementary information, Fig. S9a). Here, VEGFA is linked to central nervous system cancer.