To further determine the function of HIF-2α, we overexpressed HIF-2α (HIF-2α OE) in MCF7 and T47D, as well as knocked down HIF-2α (HIF-2α KD) in MCF7 MS and T47D MS by lentiviral infection and compared the knockdown efficiency (Fig. S3E–G). This evidence concerns the gene EPAS1 and infection.