To explore the potential application of SINEs during CBE-mediated gene correction, we assessed the effects of KPT330 on A3A CBE editing in a cell-based disease model of Marfan syndrome, where a T7498C mutation was introduced into the FBN1 gene of HEK293T cells to model the pathogenic C2500R mutation57. This evidence concerns the gene FBN1 and Marfan syndrome.