We also analyzed CD8+ T cells, M0 macrophages/microglia, and M1 and M2 macrophage populations in the glioblastoma TME, as well as selected inflammation-related molecules—cyclooxygenase 2 (COX-2) as a rate-limiting enzyme in the production of prostaglandins, e.g. PGE2 that is reportedly associated with glioblastoma immunosuppression and tumorigenesis32. The gene discussed is CD8A; the disease is glioblastoma.