When considering the lipid metabolism-related genes, sterol regulatory element binding transcription factor 1 (SREBF1) and another 10 genes (DLK1, CIDEA, LDLR, LEPR, TLR5, PDK4, ACLY, G0S2, MFSD2A, and SERPINE1) that are involved in reducing triacylglycerol concentration were found differentially expressed between H- and L-RFI steers in KC cattle. This evidence concerns the gene SREBF1 and keratoconus.