From the NK cell subsets, proinflammatory cytokines such as IFNG and TNF; chemokine, XCL1, which could promote cDC1 recruitment critical for antitumor immunity;21 as well as TNFSF14, which is important for antitumour function of NK cells via DC maturation;22 were all depleted from S2 tumours but enriched in S1 or S3 tumours (Fig. 3b). This evidence concerns the gene MPPE1 and neoplasm.