Since IL-23 is produced by activated myeloid cells including macrophages and DCs and IL-23R is expressed by activated DCs and macrophages, IL-23 is able to drive an autocrine loop within the immune system, leading to the production of a number of inflammatory mediators that contribute to the pathologies associated with NASH and NAFLD57. This evidence concerns the gene IL23A and metabolic dysfunction-associated steatohepatitis.