In addition, we found that both depletion of Skp2 (Fig. 5A) and IR treatment (Fig. 5C) significantly increased the FBW7 and Mcl-1 interaction, thus promoting FBW7-mediated phosphorylated-Mcl-1 degradation and ultimately sensitizing CRC cells to radiotherapy. This evidence concerns the gene MCL1 and colorectal carcinoma.