Because GSK3β-induced Mcl-1 phosphorylation enhanced FBW7-mediated Mcl-1 degradation and FBW7 is frequently mutated in around 15–20% of human CRC, we next examined the interaction between Mcl-1 and the E3 ligase FBW7 in CRC cells. This evidence concerns the gene FBXW7 and colorectal carcinoma.