CircTMTC1 knockdown enhanced E-cadherin expression but suppressed the expression of N-cadherin, MET, eIF4G1, Snail, c-Myc, Cyclin D1, and Survivin and the phosphorylation of MET and eIF4G1 (Fig. 8F, G), demonstrating that circTMTC1 promoted NPC growth, proliferation, and EMT by regulating the miR-495-MET-eIF4G1 axis. Here, EIF4G1 is linked to nasopharyngeal carcinoma.