In total, recurrent (>3) MEI were observed in 329 protein-coding genes of which 28 genes are annotated in the Cancer Gene Consensus with either oncogenic (ALK1, ERBB4, TSHR, PREX2, CTNNA2, CTNND2) or tumour suppression roles (EBF1, LRP1B, PTPRD, GPC5, ROBO2, PTPRT) (Fig. 6e). This evidence concerns the gene GPC5 and cancer.