OX40/OX40L blockade downregulated multiple genes involved in autophagy.35 Accumulating evidences support that autophagy promotes cell death through degradation of anti-apoptotic and cell survival factors in cancer.36 In DLBCL, patients with high Beclin1 expression achieve better OS, PFS, and overall response rate to R-CHOP.37 Furthermore, autophagy also represents a promising strategy of cancer treatment. The gene discussed is BECN1; the disease is cancer.