Moreover, we performed multicolor flow cytometry to examine the role of miR130b in immune checkpoint genes including PD-L1, CD80, 4-1BBL, LAG3, TIGHT, TIM3, and VISTA on lymphoma cells in the miR130b-overexpressing DB co-culture system and miR130b-knockdown OCI-ly10 co-culture system. This evidence concerns the gene LAG3 and lymphoma.