This greatly builds on findings from previous CLL studies as we identified several known (i.e., H3K27Me3, MCL1, and BCL2L11) and novel (i.e., NCSTN, SGK3, HSPD1, VTCN1, TRAP1, SOD1, and TAZ) proteins prognostic for OS, TTFT, and TTST [26–29]. Here, SOD1 is linked to B-cell chronic lymphocytic leukemia.