Several molecular factors influence CLL biology and prognosis: Immunoglobulin Heavy Variable mutation status (IGHV, Unmutated U-/Mutated M-CLL), cytogenetic aberrations (deletions 17p, 11q, and 13q and trisomy 12), and high expression of ZAP70 and CD38 [2–6]. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.