Both S100A4, a calcium-binding protein, and IGFBP2, an insulin-like growth factor-binding protein have roles in a multitude of cancer hallmarks including proliferation, angiogenesis, migration, invasion, and epithelial‐to‐mesenchymal transition, but their roles in CLL have not been characterized [40, 41]. This evidence concerns the gene S100A4 and B-cell chronic lymphocytic leukemia.