RNA-binding FMRP is a translational regulator (Darnell et al., 2011; Greenblatt and Spradling, 2018) known to facilitate PKA signaling (Berry-Kravis et al., 1995; Kelley et al., 2007), which is lost in the FXS, the commonest heritable cause of intellectual disability and ASD (Harris et al., 2008). The gene discussed is FMR1; the disease is Intellectual disability.