RNA-binding FMRP is a translational regulator (Darnell et al., 2011; Greenblatt and Spradling, 2018) known to facilitate PKA signaling (Berry-Kravis et al., 1995; Kelley et al., 2007), which is lost in the FXS, the commonest heritable cause of intellectual disability and ASD (Harris et al., 2008). This evidence concerns the gene FMR1 and fragile X syndrome.